Comedy Store founder and owner Mitzi Shore has died ... TMZ has learned.

Mitzi, the mother of Pauly Shore, died in L.A. Wednesday morning after battling an unknown neurological disorder for years.

Mitzi's Comedy Store was the launching pad for some of the biggest comics in the world, including Robin Williams, Richard Pryor, David Letterman, Jay Leno, Jim Carrey, Chris Rock, Arsenio Hall and Roseanne Barr.

Mitzi had been in hospice for a while, and Pauly took her to the Comedy Store Monday afternoon to say goodbye.

The Comedy Store opened its doors in 1972 on the Sunset Strip, where it has become a landmark for tourists as well as locals in Los Angeles. The huge names who got their start there would famously return unannounced to test out material.

Case in point ... imagine seeing Richard Pryor do a 2 minute set, before introducing an up-and-comer named Robin Williams. 

Comics who performed at the venue recently knew the end was near, because over the last few weeks they would tell the audience to pray for Mitzi. Pauly said Mitzi was not in pain in her final days.

She's survived by 4 children.

Mitzi was 87.


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